What is NAD+ (Nicotinamide Adenine Dinucleotide)?
NAD+ is an essential coenzyme found in every living cell, acting as a primary player in cellular energy production (ATP synthesis), mitochondrial health, and DNA repair. It serves as a fuel source for sirtuins—a family of proteins that regulate cellular longevity and metabolic pathways.
As organisms age, cellular NAD+ levels decline dramatically, dropping by up to 50% by middle age. This decline is linked to mitochondrial dysfunction, reduced energy levels, cognitive decline, and accelerated cellular aging.
Why Injections are Superior to Oral Supplements
While oral NAD+ precursors (like NR and NMN) are popular, they must pass through the liver and digestive tract, where they are largely broken down before reaching systemic circulation. Direct NAD+ injections bypass the digestive system, delivering the active coenzyme directly into the bloodstream.
This results in 100% bioavailability, allowing cells to immediately uptake and utilize the coenzyme to restore mitochondrial ATP production, enhance mental clarity, and promote cellular repair.
Reconstitution & Storage Stability
NAD+ is typically sold in 500mg or 1000mg vials due to its larger research dosages. Because NAD+ is highly sensitive to moisture and temperature, it must be handled with care:
1. Add 5.0 ml of bacteriostatic water to a 1000mg vial to yield a concentration of 200mg/ml.
2. **Refrigeration is Mandatory:** Once mixed, NAD+ is susceptible to hydrolysis (breaking down in water). It must be kept refrigerated at 2-8°C and shielded from light. Reconstituted NAD+ is best evaluated within 21 days for maximum potency.